Currently, oral rigosertib is being developed as a combination therapy together with azacitidine for patients with higher-risk MDS who require HMA therapy. A Phase 1/2 trial of the combination therapy has been fully enrolled, and the updated efficacy and safety data was presented at the ASH 2019 Annual Meeting in December 2019.
Jun 12, 2020 · "RAS pathway mutations were observed more frequently in patients that progressed on HMA therapy than those that failed HMA therapy completely. Understanding the association between RAS mutations Jul 08, 2020 · Astex Pharmaceuticals, Taiho Oncology, and Otsuka Pharmaceutical Announce FDA and Health Canada Approval of INQOVI® (Decitabine and Cedazuridine) Tablets, Oral Hypomethylating Agent (HMA) Therapy Jun 15, 2019 · “The combination regimen was well-tolerated and was given in continuing cycles for >2 years, even in those who did not respond to HMA therapy,” said Navada. Jun 23, 2020 · Combination therapy of oral rigosertib with azacitidine, the standard of care in HR-MDS, has also been studied. Currently, oral rigosertib is being developed as a combination therapy together with azacitidine for patients with higher-risk MDS who require HMA therapy.
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At HMA, we make it easy for you to get the information and care you need to lead a healthier life. Check out the helpful links above or click "Log in to myHMA" to create a myHMA account for access to enhanced tools and resources that help you understand every detail of your plan. HMA is Proving What's Possible in Healthcare®. Our team of caring experts design and deliver high-quality, innovative, and affordable health plans for self-funded employers. We are the service-oriented partner employers trust to protect two of their most important assets; their people and their health plan dollars. Jan 14, 2015 · “Hypomethylating (HMA) agents such as AZA and LEN are currently the front line of therapeutic choice for patients with higher-risk MDS, and also frequently used in elderly AML patients not otherwise eligible for standard intensive therapy,” said DiNardo.
Jun 15, 2019 · “The combination regimen was well-tolerated and was given in continuing cycles for >2 years, even in those who did not respond to HMA therapy,” said Navada.
Jan 14, 2015 · “Hypomethylating (HMA) agents such as AZA and LEN are currently the front line of therapeutic choice for patients with higher-risk MDS, and also frequently used in elderly AML patients not otherwise eligible for standard intensive therapy,” said DiNardo. Across the country, our HMA team is working with clients to provide detailed analysis, strategic insights and comprehensive support for the most immediate needs. At the same time, we continue to work with our clients to develop and implement long-term plans, projects, and solutions. Outcomes of Patients with MDS Who Achieve Stable Disease after Treatment with HMA: MDSCC Experience n=846 • Patients who achieved a BR of SD had a longer OS compared to patients with PD. • Of patients with SD at 4-6 months, 20% achieved a better response at a later time point.